While "nontoxic" is an unregulated term, we spoke with experts to get their take on toothpastes with more natural ingredients. (Davids)(Davids)
Toothpaste is probably one of your most consistently used personal care products — twice daily, every day if you're following the American Dental Association (ADA) recommendation. That makes ingredient safety worth paying attention to, especially for those with sensitivities or ingredient concerns. But what exactly do the terms “natural” or "nontoxic" mean when it comes to toothpaste? These terms aren’t defined by law, and the Food & Drug Administration (FDA) doesn't regulate their use, but that doesn't mean it's the Wild West on the toothpaste aisle. The Federal Trade Commission (FTC) requires brands making these all-natural or nontoxic claims to have solid scientific evidence that their products are safe for people and the environment, says Dr. Christopher Tolmie, DDS of PDS Health.
According to dental experts, the definition of nontoxic comes down to preparation and ingredients. "Nontoxic toothpastes use simple, gentle formulas that are safe when used as directed. Think short ingredient lists, low-abrasion — low Relative Dentin Abrasion (RDA) powders — and no harsh detergents like sodium lauryl sulfate (SLS), which can irritate sensitive mouths or trigger canker sores," says Tolmie.
Dr. Michael J. Wei, cosmetic dentist and founder of Manhattan Cosmetic in New York City, agrees, explaining that these products avoid potentially problematic ingredients entirely. "A 'nontoxic' toothpaste is usually a toothpaste that doesn't have ingredients like microplastics, parabens, sulfates, artificial colorings and sweeteners and heavy metals," he says, adding that these options are also typically free of fluoride or contain only small amounts.
But wait — does that mean toothpastes with fluoride are “toxic”? Not so fast. It’s important to note here that fluoride itself is a highly efficacious toothpaste ingredient that remineralizes and strengthens tooth enamel and has been proven to be safe when used as directed. Dr. Steven J. Katz, president of the American Association of Endodontists, advocates for fluoride-containing formulas. "I recommend toothpastes that contain fluoride," he says. "Most of the 'nontoxic' toothpastes don't have fluoride and have agents that have not been proven to strengthen teeth like fluoride, outside of a lab." It's worth noting that these nontoxic formulas often don't carry the ADA Seal of Acceptance (the gold standard of safety and efficacy in dental care products). In fact, none of the pastes included on our list bear the seal. While many have undergone third-party testing to verify the safety of their ingredients, there are various reasons a brand may choose not to pursue ADA evaluation (including the cost of testing). However, the absence of the seal does mean there's a chance these pastes may not be as effective as those that do carry it.
However, if you're dead set on trying "nontoxic" or "natural" toothpastes, the experts we spoke to say your focus shouldn't necessarily be on skipping fluoride, but on choosing products with ingredients that won't irritate your mouth or selecting those with low abrasiveness levels that are less likely to wear down your enamel over time. On top of that, if you're concerned about ingredients with controversial reputations — like certain preservatives (e.g. parabens) that have been flagged in some studies for potential hormonal effects — you may prefer formulas that leave them out entirely.. The good news is that there are effective options that will clean your teeth well.
To find the best nontoxic toothpastes and the best natural toothpastes, the Yahoo team consulted four dental experts for their guidance. We then researched the best options on the market and tested 10 products ourselves, prioritizing those with transparent ingredient lists, proven active ingredients, formulas free from the most concerning ingredients and positive user feedback. But you should keep the bigger picture in mind when making your selection. As Tolmie states, "Brushing, flossing, smart eating and regular dental check-ups do most of the work — toothpaste is the support, not the star."
So if you're looking to trade some of the artificial additives for naturally sourced ingredients, this list can help deliver on both safety and sparkle.
Not interested in giving up your favorite toothpaste? No worries. We tested more-traditional options too (most carrying the ADA Seal of Acceptance). Check out our top picks for best toothpastes and best whitening toothpastes.
Active ingredient: Nano-hydroxyapatite | Flavor: Natural Peppermint | Size: 5.25 oz | Standout features: Contains micro polishing agents to whiten without sensitivity and zero fluoride
Why we love it
Davids Premium Sensitive + Whitening Toothpaste earns our top spot for delivering effective results without relying on controversial or potentially irritating ingredients. It’s one of the few natural pastes to carry the Environmental Working Group (EWG) Verified mark, meaning its entire ingredient list has been independently assessed for potential safety concerns, including hormone disruption, carcinogenicity, and reproductive toxicity.. This third-party safety validation gave us the confidence to classify it as our top pick in this category of toothpastes.
The star ingredient, nano-hydroxyapatite, is a biomimetic mineral, meaning it's essentially tooth repair in a tube. Japan figured this out three decades ago, and we're finally catching up, although the FDA hasn't approved its use in dental products, and the ADA hasn't given its Seal of Acceptance to products that contain the mineral. Nano-hydroxyapatite rebuilds and remineralizes teeth by depositing natural calcium phosphate crystals directly onto the surface of the tooth. This means it's particularly effective for sensitive teeth, as it helps fill tiny tubules in the dentin that cause sensitivity pain. And while the FDA and ADA haven't approved its use in dental products, it has been widely used in periodontology and in oral and maxillofacial surgeries for years due to its ability to stimulate bone growth. The European Commission has also approved its use in toothpastes up to a concentration of 29.5%.
David's uses a low RDA blend that's kind to enamel while still leaving your teeth squeaky clean. Plus, you won't find any SLS, artificial sweeteners or synthetic dyes, just clean ingredients like organic coconut oil for its antimicrobial properties and delicious natural peppermint oil for fresh breath.
Editor's take
One of the things I loved most about this toothpaste was the mellow taste. It left my mouth feeling exceptionally clean and fresh, but without the harsh, aggressively minty flavor of some options. If you're anti-mint, you can also try their orange and vanilla flavor. The texture was also pleasant and silky, and while it didn't foam as much as conventional toothpastes because it's SLS-free, it still felt good during use.
What users say
I'm not the only one who rates this product five stars. A satisfied Amazon user raves, "Highly recommend to anyone looking for a clean, effective toothpaste that’s gentle on sensitive teeth!" Another adds, "David’s has been my favorite so far, the taste is so pleasant, it’s not chalky or weird. My teeth feel so clean and fresh even the next morning. My sensitivity is gone and my gums are not bleeding anymore."
Safety tip
Just be careful to keep it out of reach of pets, as it contains the sweetener xylitol, which is toxic for our furry friends.
Active ingredient: Nano-hydroxyapatite | Flavor: Fresh Peppermint | Size: 4.0 oz | Standout features: 10% nano-hydroxyapatite
Why we love it
Mouthology is our best natural toothpaste as it delivers exceptional results with naturally derived ingredients. While it doesn't carry the EWG Verified mark, this pick impressed me with its ingredient composition and all-around performance. The notable feature is its 10% nano-hydroxyapatite concentration — one of the highest I've seen — providing superior benefits for remineralization and enamel repair compared to many other plant-based, natural options (particularly those that don't include nano-hydroxyapatite or fluoride).
What makes Mouthology particularly appealing if you're in the market for a natural toothpaste is its commitment to avoiding synthetic additives. It combines its nano-hydroxyapatite formula with xylitol to fight tooth-decay-causing bacteria, delivering a double punch against tooth decay. And, you won't find any fluoride, SLS or artificial ingredients in it.
Editor's take
I loved the creamy texture. It was a refreshing change from the gritty offerings of others in this class, and left my teeth feeling spotless. The fresh peppermint flavor was also enjoyable without any cloying sweetness.
What users say
As one 5-star Amazon reviewer reports, "Finally, a Natural Toothpaste That Actually Works!" They continue, "I’m never going back. My teeth feel so clean and smooth after every brush, and I love that it’s fluoride-free but still helps with sensitivity. The fresh peppermint flavor is really nice and not overpowering. I’ve noticed my teeth look whiter and my mouth feels healthier overall. Highly recommend if you’re looking for a more natural toothpaste that actually works."
Active ingredient: Nano-hydroxyapatite | Flavor: Peppermint | Size: 1.3 oz / 62 tablets | Standout features: Convenient foaming tablets
Why we love it
If you've never tried toothpaste tablets before, our top pick, Huppy Toothpaste Tablets, is the perfect introduction to this convenient and innovative format. These compact tablets remove the need for plastic tubes and cardboard boxes while delivering all the cleaning power of standard squeezey paste. Simply chew a tablet, add water to your mouth with your wet toothbrush and brush as usual. The convenience factor is unmatched, especially for travel, and Tolmie recommends these tablets for their clean-label and minimal ingredients that strengthen enamel.
Huppy stands out because of its focus on effective, natural ingredients like coconut, tea-tree and peppermint oil, without unnecessary additives. The nano-hydroxyapatite remineralizes teeth and reduces sensitivity, while the tablets ensure you get a precise dose every time — no more squeezing out too much paste or dealing with messy tubes, especially when squashed in luggage! The zero-waste aspect is another bonus for environmentally conscious folks, as the tablets come in a reusable metal tin and plastic-free packaging.
Editor's take
As someone new to the tablet format, I was initially skeptical about whether they'd offer as satisfying a clean as toothpaste. But, I'll admit, I'm somewhat of a convert. The tablets create a pleasant foam when mixed with water, and the cleaning sensation is just as thorough as conventional paste. Will buy again!
What users say
An Amazon reviewer says, "These little tooth-cleaning tablets are awesome!" They add, "What I love most is how convenient they are for travel. No messy tubes, nothing to leak in your bag. You just toss in as many tablets as you need, and you’re good to go. They save space, they’re super practical, and I don’t have to worry about TSA liquid limits either."
Active ingredient: Nano-hydroxyapatite | Flavor: Peppermint | Size: 4.2 Oz | Standout features: EWG Verified, vegan, cruelty-free, sugar-free, fluoride-free
Why we love it
Looking for a gentle whitening toothpaste? Attitude Fluoride-Free Whitening Toothpaste offers evidence that you don't need harsh substances to achieve a brighter smile. Dr. Jeremy Manuele, Board-Certified Orthodontist and Author of The MARPE Advantage, explains that whitening toothpaste typically contains mild abrasives or small amounts of peroxide to help remove surface stains. This EWG Verified option takes a different approach — earning our top nontoxic whitening spot because it left my teeth whiter in a matter of days, using only plant and mineral-based ingredients independently screened for safety concerns.
There's no need to worry about the high-abrasion formulas or synthetic peroxides of conventional products, as Attitude uses effective natural whitening agents to remove surface stains without damaging enamel. You can also side-step the uncomfortable tooth sensitivity that often comes with whitening products. The plant-based recipe has no potentially toxic ingredients, according to the EWG. It's also completely vegan and cruelty-free.
Editor's take
I was impressed at how effective this toothpaste was at removing surface stains from the oceans of coffee and tea I drink every day! I also enjoyed the peppermint flavor, which was refreshing without being overpowering and the light, foamy consistency.
However, as Manuele cautions, "Whitening toothpaste can brighten your smile — but during orthodontic treatment, it can also leave uneven results once the brackets come off," so those with braces should consult their orthodontist first before using.
What users say
An Amazon reviewer rated it 10 out of 10, saying, "The quality is great, even better than the brands with toxins, actually works great for sensitive teeth like I have, doesn’t have too gritty of a texture, and actually leaves your breath fresh! The taste is amazing like spearmint gum!"
Active ingredient: Baking soda, xylitol, kaolin clay | Flavor: Spearmint | Size: 3.5 Oz | Standout features: EWG Verified, PETA and Vegan Society certified, 10% proceeds donated
Why we love it
With My Spearmint Toothpaste is our top vegan option because it goes beyond simply avoiding animal ingredients and represents a complete commitment to ethical living. Besides being EWG Verified as containing no toxic ingredients, this toothpaste is both PETA and Vegan Society certified, meaning it meets the strictest standards for vegan products. The brand also decided to eliminate glycerin to avoid palm oil use, addressing the issue of deforestation through palm oil derivatives, something that some other vegan brands overlook. Plus, with every purchase, 10% of proceeds go toward providing life essentials like safe drinking water and education to those in need.
The toothpaste has a remarkably straightforward ingredient list, with natural components like kaolin clay, green tea extract and organic rosemary that work together to clean teeth without harsh chemicals. You won't find any of the usual suspects — looking at you, parabens, SLS, triclosan and artificial colors — just effective plant-based ingredients that are safe for the whole family. Xylitol provides natural cavity-fighting properties, while baking soda whitens and neutralizes acids.
Editor's take
This toothpaste exceeded my expectations. I'll admit I was cynical that a formula without conventional cleaning agents could deliver real results, but I was impressed. My teeth felt immaculate after each use, though it didn't tackle surface stains quite as effectively as our top overall or whitening picks.
The main drawback with this product is that it doesn't contain fluoride or nano-hydroxyapatite — two ingredients used to strengthen enamel.
So, while products like With My are great for cleaning and freshening, they can't offer the same level of cavity protection as fluoride-based products.
Active ingredient: Fluoride | Flavor: Peppermint | Size: 4.0 Oz | Standout features: Whole mouth care that whitens teeth, prevents tartar buildup and freshens breath
Why we love it
Tom's of Maine Whole Care is an easy "best with fluoride" choice as it bridges the gap between natural ingredients and proven cavity prevention. "Fluoride is safe when used as directed, and in the appropriate amounts. It is the most researched and effective ingredient used to strengthen teeth and prevent decay," says Katz. He also emphasizes fluoride's importance from a clinical perspective: "As an endodontist, I value fluoride. It helps prevent the kinds of deep decay that lead people to my chair."
While Katz doesn't specifically recommend the Tom's of Maine brand, this is one option that does include fluoride as the active ingredient at a level of sodium monofluorophosphate (0.13% weight per volume fluoride ion) comparable to other fluoride toothpastes (for instance, Colgate Optic White Advanced, our top pick for best toothpastes, also contains sodium monofluorophosphate at a 0.12% weight per volume fluoride ion). So if you're otherwise looking for more natural ingredients but aren't ready to give up fluoride's protective benefits, Tom's is a good option.
Editor's take
I appreciated this "six benefits in one" blend that fights cavities, strengthens enamel, promotes remineralization, whitens teeth, prevents tartar buildup and freshens breath. It does all this without artificial sweeteners, preservatives, colors or flavors. I loved the peppermint-forward flavor, which tasted almost as natural as chewing peppermint leaves. The paste was thinner than some of the others I've tried, so you have to be careful when you squeeze. That said, it still produced an excellent foam that left my teeth and mouth feeling spotless.
What users say
As one Amazon user neatly sums it up, "This is the best toothpaste I have ever used by far. My teeth feel clean, there's no coloring, there's fluoride."
Choosing the best “nontoxic” or “natural” toothpaste means paying attention to a few essentials. Here's what to consider:
The most important consideration is the active ingredient that will actually protect your teeth. Tolmie recommends looking for "one clear active ingredient, like fluoride or hydroxyapatite" rather than getting distracted by marketing claims. If you're avoiding fluoride, nano-hydroxyapatite is your best alternative.
One factor many people overlook is how abrasive their toothpaste is. Tolmie emphasizes looking for "low abrasiveness value — RDA — on the ingredient label." The American Dental Association (ADA) considers an RDA of 250 or less to be safe, but lower numbers are gentler on your enamel. "Skip charcoal and extra-gritty formulas; they can scratch enamel," he warns.
Your personal dental history should guide your choice. Manuele points out that "every mouth has a different story," and recommends considering whether you're "more prone to cavities, gum recession, enamel wear or dry mouth."
For example, sensitive teeth benefit from gentler formulas, while those prone to cavities need stronger enamel protection. If your gums are problematic, then prioritize anti-inflammatory ingredients, and you should avoid alcohol-based formulas if dry mouth is a concern.
Rather than trusting marketing claims alone, choose products with independent validation. Tolmie recommends checking "the ADA Seal database to see if a product was independently vetted." For nontoxic claims, the EWG Verified mark is your best bet, as it means the product has been rigorously screened for safety concerns.
Look for brands that clearly list all ingredients and avoid vague terms. Products should specify exactly what active ingredients they contain and in what concentrations. Tolmie emphasizes that "short ingredient lists" are often preferable to complex formulations with numerous additives.
To find the most effective natural toothpastes, we built our selection process around expert guidance and real-world testing. Four dental professionals shared their insights on what they believe makes a toothpaste nontoxic and which ingredients can deliver results for consumers who are looking to avoid certain chemicals or additives.
Armed with this knowledge, we scoured the market for products with clean ingredient profiles and strong user feedback. We favored those with EWG Verified marks over those making unsubstantiated "natural" claims. From dozens of options, we narrowed our list to 10 contenders.
The real test came next. I personally used each one for 4 days, brushing twice daily to evaluate everything from initial taste and texture to long-term mouth feel and cleaning power. Only the products that I felt delivered on their promises made our final recommendations.
When it comes to toothpaste, there is no standard definition, which is why the terms “nontoxic” and “natural” are often used interchangeably. Generally, "nontoxic" refers to toothpastes that prioritize gentle, safe ingredients over harsh chemicals. According to Tolmie, these products typically have streamlined ingredient lists and avoid potential irritants that could disrupt your mouth's natural balance.
Wei points out that the appeal of these toothpastes often lies in their simplified approach to oral care. Rather than relying on synthetic preservatives and harsh detergents, these products focus on alternatives that work with your mouth's natural processes.
Officially, the FTC states that companies using "nontoxic" claims must provide scientific evidence to underpin these safety assertions for health and environmental impact.
When checking if a product is nontoxic, you need to look beyond marketing claims. Tolmie suggests checking for a clear active ingredient (fluoride or hydroxyapatite) and confirming the product's RDA value for abrasiveness. The ADA Seal of Acceptance shows a product's claims have been independently reviewed for safety and effectiveness.
Wei emphasizes the importance of examining ingredient lists when the ADA seal isn't present. Look for third-party certifications like the EWG-verified mark, which indicates rigorous independent screening for safety concerns, including hormone disruption, cancer risk and reproductive toxicity.
Be wary of vague terms like "natural" or "clean" without supporting evidence, and research unfamiliar ingredients to understand their safety profiles and potential effects.
The decision ultimately depends on your individual oral health needs and personal values. Wei notes that people with sensitive teeth or gums may benefit from natural formulations since they tend to be less abrasive than conventional options. Tolmie adds that if you experience mouth sensitivity or prefer products with fewer additives, natural toothpastes can help maintain oral comfort while supporting healthy brushing habits.
Additionally, these products appeal to consumers interested in reducing their exposure to synthetic chemicals and supporting environmentally conscious brands. However, you should weigh these benefits against your oral care requirements.
The effectiveness of nontoxic toothpastes largely depends on their active ingredients. Manuele explains that some formulas are effective, in that they safely and adequately clean your teeth. He adds, "But many lack fluoride — making them risky for orthodontic patients. If you're going fluoride-free, make sure your natural toothpaste includes something that protects enamel — like nano-hydroxyapatite."
Katz echoes the concern about fluoride-free options: "Natural, herbal, anti-microbial and charcoal toothpaste, more often than not, don't contain fluoride. The disadvantage of these toothpastes is that consumers lose the tooth-strengthening benefits of fluoride."
That said, Wei notes that effectiveness really comes down to your specific needs. For those with concerns about tooth decay or weakened enamel, fluoride is crucial for strengthening enamel and preventing cavities.
Many dentists caution against charcoal toothpastes because they tend to be more abrasive and often lack fluoride, which can increase the risk of enamel wear and cavities over time. This enamel wear expose the underlying tooth structure called dentin, leading to tooth sensitivity and decay, which may then require root canal therapy.
Tolmie adds that people prone to canker sores should steer clear of foaming agents like SLS. If you're sensitive to flavors or colors, consider opting for dye-free and artificial flavor-free options.
You may also choose to avoid triclosan, an antimicrobial ingredient, due to potential negative effects on gut health. While the research is still developing, some people prefer to err on the side of caution.
Several mouthwash alternatives exist; however, none are EWG Verified. Tolmie recommends alcohol-free rinses that use cetylpyridinium chloride or essential oil blends to freshen breath and combat plaque without the burning sensation of traditional mouthwashes.
Manuele says, "Natural mouthwashes generally don't contain synthetic chemicals and artificial flavors. Instead, they contain plant-based or mineral ingredients like aloe vera, essential oils (peppermint, clove, tea tree), xylitol or mineral salts." However, he cautions, "Natural doesn't always mean effective or even safe, so it's worth digging into the details."
Absolutely! Wei strongly recommends consulting your dentist, especially if you're unsure about making the switch. Dental professionals can provide personalized recommendations based on your unique oral health needs and history.
Hello Antiplaque Toothpaste: Wei recommended this toothpaste, and I agree that it's a good fluoride-free option, also free of parabens, dyes, sulfates and artificial sweeteners. However, it didn't leave my breath feeling particularly fresh.
RiseWell Mineral Toothpaste: I really liked this toothpaste, and Tolmie is also a fan. The wild mint flavor was long-lasting, and my whole mouth felt clean after use. The only real downside was the $19 price tag.
Fygg Fluoride Free Toothpaste: This unique toothpaste is formulated with probiotics to support the oral microbiome. I went out on a limb and tried the chocolate flavor, which was a mistake! I missed my usual minty freshness, but I'd be very interested in trying their other options in the future.
Livfresh Toothpaste: This was my splurge choice in our review of best toothpastes. It's SLS-free and has no abrasives, sulfates, phthalates or parabens. It's also free of triclosan, gluten and sugar. It's an amazing option if you have $25 to invest, but many may find this too pricey.
Dr. Michael J. Wei, DDS, Founder of Manhattan Cosmetic in New York City, specializing in general, cosmetic and restorative dentistry. New York City
Dr. Christopher Tolmie, DDS, MBA, Multi-Practice Owner Doctor, PDS Health, Miami, Fla.
Dr. Steven J. Katz, DDS, MS, president of the American Association of Endodontists, Beachwood, Ohio
Dr. Jeremy Manuele, DMD, board-certified orthodontist and author of The MARPE Advantage, Las Vegas
Our health content is for informational purposes only and is not intended as professional medical advice. Consult a medical professional on questions about your health.
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