When you're hit with a cold or the flu, it's important to have the best symptom-relieving meds on hand. (DayQuil, NyQuil, Mucinex, Sudafed, Tylenol)
While a stuffy nose, scratchy throat and body aches can stop you in your tracks, the best cold medicine can help you bounce back faster and feel more like yourself. But facing packed drugstore shelves when you're already miserable can make finding relief yet another headache.
This common challenge affects millions. With the average adult catching two to three colds each year per the CDC, it's no wonder 93% of Americans reach for over-the-counter (OTC) medications before calling their doctor. And since the typical U.S. household spends over $300 annually on flu and common cold meds, choosing the right treatment isn't just about feeling better — it's about saving money too.
That's why we took the guesswork out of your next drugstore run. I first consulted primary care physicians and pharmacists to zero in on the best flu and cold symptom soothers out there, then I used my own experience as a nurse to narrow down the options. Read on to find the perfect match for feeling better fast. But remember: While the best cold and flu medicine can ease symptoms, you need to call your doctor if you have a fever or sore throat lasting more than three days, or if symptoms worsen or continue beyond two weeks.
Update, Aug. 27, 2025: We checked all product prices and availability. Our No. 1 pick for the best cold and flu medicine remains unchanged.
While there's no cure for the common cold, you can ease symptoms while your body heals. Over-the-counter medications can help, but Mayo Clinic experts recommend these proven natural cold and flu remedies, especially for those managing other medical conditions or prescriptions:
Saline nasal drops and rinses for congestion
Lukewarm baths or cool compresses to reduce fever
Water, electrolytes and herbal teas for hydration
Saltwater gargles for sore throat relief
Honey to soothe a sore throat (if over age 1)
A cool-mist humidifier to help ease stuffiness
These simple remedies have stood the test of time and scientific scrutiny. However, when it comes to other natural cold remedies, the evidence is less clear. Plus, none are FDA-approved. Always consult your health care provider before trying alternative approaches, especially if you take other medications or have underlying conditions. With that, here are a few of the most commonly used natural cold and flu remedies and what science says about them:
Elderberry: Rich in antioxidants and vitamins, it's thought that elderberries may help soothe cold and flu symptoms by reducing congestion and possibly making you sweat more. While some studies suggest its extracts and syrups can fight viruses, research remains inconclusive.
Zinc: This mineral plays a vital role in immune function, but research on its cold-fighting powers is mixed. While some studies suggest it may shorten colds, others show no benefit.
Echinacea: Available in teas, supplements or tinctures, this herb may slightly reduce cold symptoms if taken when symptoms first appear. However, research is mixed on its effectiveness.
With drugstores and grocery aisles full of OTC cold and flu medications, picking the right one can feel like a guessing game. The trick is to ensure the product matches your specific symptoms and situation. Here's what to consider when choosing the best cold medicine for you:
Symptoms: Select a product that specifically targets your symptoms, such as congestion, sore throat or cough. Don't use a combination medicine if you don't need it all, says Kerley.
Active ingredients: Check the label for active ingredients to ensure you're not doubling up on medications if you take multiple products.
Brand choice: While reputable brands are reliable, ask your pharmacist about generic versions. They often contain identical active ingredients at lower prices.
Form of medication: Pick what works best for you — tablets, liquids, capsules or dissolvable powders.
Age and dosage: Ensure the product is appropriate for the user's age and follow the dosage instructions carefully, using only the included dosing device.
Potential interactions: Consider how the medicine may interact with your OTC or prescription medications and supplements. When in doubt, consult your doctor or pharmacist.
Underlying conditions: Consult a health care professional if you have a chronic condition like high blood pressure, diabetes or heart issues, as some cold medicines may be unsafe.
Allergies or sensitivities: Check for ingredients that might trigger allergies or sensitivities, such as dyes, preservatives and artificial flavors.
Drowsiness effects: Be aware of whether the medicine may cause drowsiness or interfere with daily activities, especially if you need to drive or work.
To find the best cold and flu remedies, I first tapped my own expertise as a registered nurse who has seen countless patients suffer through cold and flu season. Next, I consulted pharmacists and medical doctors to discuss not only the most effective symptom-soothing ingredients, but also the ones backed by solid research with the strongest safety profile. Together, we carefully evaluated both over-the-counter and natural options, considering their effectiveness and potential side effects. After examining real-world experiences, this practical approach helped us zero in on the best cold and flu remedies worth adding to your medicine cabinet.
No, there is no cure for the common cold or flu. OTC medications are designed to ease symptoms, providing relief while the body fights off the illness. They won't cure, prevent or shorten how long your illness lasts.
While you can combine different medicines to target specific symptoms, be careful not to double up on active ingredients like acetaminophen, which can be dangerous. Many combination products that treat multiple symptoms are safer and more convenient than taking several separate medicines. When in doubt, check labels carefully or ask your pharmacist.
No. For example, children younger than 6 years old should not use over-the-counter cold medications. And those with unique health needs or folks taking other medications or supplements should exercise caution as well. Consult your provider to ensure any OTC or natural remedy you choose is safe and won't interfere with any preexisting conditions or medications you're already using.
Common side effects include dry mouth and jitteriness. Some cold medicines act as stimulants that may leave you wired, while others can make you drowsy. Read labels carefully to choose products that won't interfere with your daily activities.
Always follow the dosage and duration instructions on the label. Beyond that, if your fever or sore throat lasts more than three days, or if symptoms worsen or continue beyond two weeks, reach out to your health care provider. Do the same if you experience any unpleasant side effects.
Mucinex InstaSoothe Sore Throat Lozenges: The combo of honey and research-backed hexylresorcinol proves to be an effective sore throat soother. They're also menthol-free, which is a win for many who dislike that cooling sensation. Note that these drops contain corn syrup and artificial colors.
Tylenol Cold + Head Congestion Severe: Acetaminophen tackles fever and body aches, while guaifenesin helps break up chest congestion in this version of Tylenol. But be aware that its decongestant (phenylephrine) has recently been deemed ineffective for nasal congestion by the FDA.
Mucinex Fast-Max Cold & Flu Medicine: Yes, another Mucinex product! When regular Mucinex won't cut it, Bourgeois suggests this version. It contains numerous active ingredients that work together to relieve pain, quell cough, clear chest congestion and thin mucus — nearly everything you need when you need everything! (Just know, it also contains phenylephrine.)
Jennifer Bourgeois, PharmD, a pharmacy and health expert for SingleCare
Bayo Curry-Winchell, MD, a family physician and medical director at Saint Mary's Urgent Care in Reno, Nev.
Summer Kerley, PharmD, pharmacist and vice president of clinical operations at Rite Aid
Our health content is for informational purposes only and is not intended as professional medical advice. Consult a medical professional on questions about your health.